Table 2 Summary of parameters used to simulate alternate hypotheses of how human liver regeneration differs from rat liver regeneration
Hyp 1: Altered cytokine response | Hyp 2:Altered GF storage and ECM balance | Hyp 3: Altered state transition rate | Hyp 4: From Periwal et al. [29] | Hyp 5: Reduced metabolic demand |
|---|---|---|---|---|
kIL6 = 0.1435 | κdeg = 4.955 | kQP = 1.4x10−3 | kQP = 1.1x10−3 | M = 20.8217 |
κIL6 = 0.4942 | κECM = 56.30 | kPR = 1.5x10−3 | kPR = 2.6x10−3 | G = 3.474x10−4 |
VJAK = 1.364x103 | kGF = 3.288x10−3 | kRQ = 70.9x10−3 | kRQ = 135x10−3 |  |
Km JAK = 7.565x103 | κGF = 2.139x10−3 |  | kreq = 4.17x10−3 |  |
κJAK = 0.0398 | kup = 0.1008 |  | kap = 4.17x10−3 |  |
[STAT3] = 2.031 |  |  | kprol = 8.33x10−3 |  |
kSTAT3 = 1.109x103 |  |  |  |  |
Km STAT = 0.5178 |  |  |  |  |
κSOCS = 0.1682 |  |  |  |  |
KI SOCS3 = 0.0569 |  |  |  |  |
kIE = 18.60 |  |  |  |  |
Km IE = 88.13 |  |  |  |  |
κIE = 1.148 |  |  |  |  |