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Fig. 5 | BMC Systems Biology

Fig. 5

From: Systems analysis of non-parenchymal cell modulation of liver repair across multiple regeneration modes

Fig. 5

Dynamic local sensitivity analysis of the regeneration model with and without cell growth. a Maximum normalized sensitivities were calculated for each parameter. b Normalized local sensitivity of metabolic demand when not considering cell growth. Metabolic demand is inhibitory for the first 53 h post-PHx, likely through increases in cell apoptosis. After 53 h, metabolic demand enhances regeneration, likely through increased production of growth factors. c Normalized local sensitivities of metabolic load and growth rate reveal a dynamic competition between replication and growth. From 43–87 h post-PHx growth rate and metabolic demand both drive regeneration. During initiation and termination, however, imbalances between growth and metabolic load can inhibit regeneration

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