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Table 1 List of metabolic engineering targets

From: Flux-sum analysis identifies metabolite targets for strain improvement

Objective

Target metabolites

Flux-sum perturbation

Experimental validation

Enhance ethanol production

Acetate

Attenuation

[25, 26]

 

Acetylphosphate

Attenuation

[25, 26]

 

Formate

Attenuation

N.A.

 

6-Phospho-D-gluconate

Intensification

N.A.

 

Erythrose 4-phosphate

Intensification

N.A.

 

5,10-Methylenetetrahydrofolate

Intensification

N.A.

 

Sedoheptulose 7-phosphate

Intensification

N.A.

Enhance succinate production

Pyruvate

Attenuation

[11]

 

Glyoxylate

Intensification

[30, 31]

 

Menaquinone/menaquinol

Intensification

N.A.

Minimize acetate production

Acetate

Attenuation

[34, 35]

 

Acetylphosphate

Attenuation

[34, 35]

 

3-Phosphoglycerate

Intensification

N.A.

 

4-Methyl-2-oxopentanoate

Intensification

N.A.

 

Isocitrate

Intensification

[36]

 

Lactate

Intensification

[34]

 

Ribulose 5-phosphate

Intensification

N.A.

 

Succinic semialdehyde

Intensification

N.A.