Figure 1From: Reshaping the epigenetic landscape during early flower development: induction of attractor transitions by relative differences in gene decay ratesSchematic representations of the modeling methodology.a) The starting point is an experimentally grounded and dynamically characterized GRN Boolean model. Here the FOS-GRN is used, which recovers ten fixed-point attractors representing the cell-types observed during early flower development. b) The Boolean model is transformed into an equivalent continuous dynamical model. A set of rules is applied to the logical propositions of the Boolean model in order to derive a logic-based ODE model in continuous state-space. c) An attractor-wise, gene-wise numerical bifurcation analysis is performed. Because of qualitative changes to the AL induced by increasing parameter values several basins of attraction may merge into one, causing an inevitable cell-fate decision (i.e., an attractor transition).Back to article page