Figure 4

Effects of promoter leakage on bursting kinetics. (A and D) no feedback: promoter leakage does not change burst size nor burst frequency, where the parameter values are the same as those used in Figure 3 (A). (B and E) negative feedback: promoter leakage does not change burst frequency, but reduces burst size, where the parameter values are the same as those used in Figure 3(B). (C and F) positive feedback: promoter leakage does not change burst size but increases burst frequency, where the parameter values are the same as those used in Figure 3(C).