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Figure 6 | BMC Systems Biology

Figure 6

From: Spatially-resolved metabolic cooperativity within dense bacterial colonies

Figure 6

Growth rates and substrate profiles over time. (A) The colony is colored by growth rate and shown in cross-section. The fastest-growing cells (red) inhabit the colony periphery, while much of the interior shows little or no growth (blue) due to nutrient depletion. The grey diagonal line shows the linear radial growth of the colony. (B) Oxygen concentration within the same colony in cross-section at 12, 13, and 14 hours. Between 13 and 14 hours, a well-defined anoxic region forms in the center of the colony. The penetration of oxygen into this colony is between 50 and 60 μm. (C) Glucose concentration in cross-section at 14, 15, and 16 hours. Beyond 14 hours, the glucose concentration in the colony interior rapidly falls, and beyond 15 hours, much of the colony interior, in addition to being anoxic, is also glucose-starved.

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