From: A curated C. difficile strain 630 metabolic network: prediction of essential targets and inhibitors
Target (pair)a | Sequence identityb | DrugBank potential inhibitorsc | |
---|---|---|---|
E.coli | Human | ||
accC | P24182 [53%] | Q96RQ3 [48%] | LZJ, LZK, LZL, OA1, OA2, OA3, OA4, OA5, L21, L22, L23 (P24182 [53%]); BTI (Q99UY8 [48%]); BTN (P11498 [45%]); D1L, H1L (O00763 [32%]) |
adk | P69441 [52%] | P54819-2 [45%] | IPE (P30085 [32%]) |
crt1 | M9BEQ1 [37%] | P30084 [44%] | QUE (Q6NVY1 [30%]) |
fabF | P0A6Q6 [49%] | Q9NWU1 [45%] | CER, P9A, PMN (P0AAI5 [50%]); TL5, TL6, P4T (P0A953 [38%]); TLM (P63454 [37%]) |
fabH | P0ACC7 [42%] | - | CER, 669, OCS (P0A6R0 [45%]); B82 (820 T1 [43%]); DCC, UDT, VZZ, D1T, DFD, MDX (P0A574 [37%]) |
fabZ | P0ADG7 [36%] | P20839 [35%] | QUE, 2BC, 2BE, 2RB, 3BE, 4BB, 4BE, AGI, EMO, SAK (Q5G940 [41%]); BDE (O25928 [41%]) |
glmU | P62617 [55%] | - | P21 (P43889 [42%]) |
guaB | P14900 [32%] | P20839 [35%] | MOA, RBV, CPR, VX-148 (P20839 [35%]) |
ispA | B1J028 [42%] | Q5T2R2 [31%] | IPR (Q83M58 [41%]) |
ispH | M8X9N5 [30%] | - | DMA, IPE (P62624 [30%]) |
ispF | P0AD61 [51%] | P14618-2 [44%] | FPP (Q8EBR3 [62%]); GPP (P62617 [55%]); IPP (A0R559 [34%]) |
murD | P0A858 [44%] | P60174-1 [44%] | LK1, LK2, LK3, LK4, LKM (P14900 [32%]); |
ntpA | - | P38606 [51%] | ADH, 911, Tiludronate, BafilomycinA1, Bafilomycin B1 (P38606, [51%]); QUE, APP, AUR, PIT, TLX (P06576 [30%]) |
ntpB | - | P21281 [53%] | Gallium nitrate, AES (P21281 [53%]); QUE, APP, AUR, PIT, TLX (P06576 [30%]) |
pykF | A0A029KL96 [52%] | P14618-2 [44%] | D8G, DYY, DZG, PGA (P14618 [44%]) |
deoD (deoB, deoC) | L3ICZ2 [46%] | P00491 [48%] | IMH, 2DI, AZG, 9PP, IMG, GU7, BC3, 9DI (P00491 [48%]) |
fabG (CD2577) | P33898 [61%] | P04406 [44%] | EMO (P16544 [37%]); TAQ, CB3, DVP, FE1 (P0CG22 [34%]); MAX (Q6PKH6 [33%]); TDB (Q16698 [31%]) |
CD2577 (fabG) | N3Z8L0 [36%] | Q92506 [33%] | TCL, IDN, AYM, BGC, 654, ZAM, 826, NDT, (P0AEK4 [39%]); NAP, TDB (Q16698 [30%]) |
gapA (gapB) | P0A9B2 [52%] | O14556 [47%] | BRZ, NMD, TND (O14556 [44%]); AES (P04406 [49%]) |
gapB (gapA) | P25526 [35%] | P00352 [35%] | APR, SND, AES (P04406 [49%]); BRZ, NMD, TND (O14556 [47%]) |
uppS (CD2762) | P0A825 [56%] | P34897-3 [45%] | B08, B28, B29, B76, FPP, FPS, IPE (P60472 [44%]); GPP (P60379 [43%]) |
glyA (CD2834) | P0A825 [48%] | P34897-3 [41%] | PLP, THL (P34897 [45%]); Mimosine (P34896 [44%]) |
CD2834 (glyA) | - | B7ZLW7 [31%] | PLP, THL (P34897 [41%]); Mimosine (Pr4896 [40%]) |
CD0727 (folD | fhs | fchA)d | P24182 [53%] | Q96RQ3 [48%] | CNC, THL, I2A (Q99707 [31%]) |
scoB (folD | fhs | fchA)d | E9YQ86 [56%] | B7Z609 [51%] | SIN, EMT (P55809 [52%]) |
scoA (folD | fhs | fchA)d | G1YD51 [53%] | Q6IAV5 [42%] | SIN, EMT (P55809 [42%]) |
CD3231 (hpt) | W1H7G6 [47%] | Q9NRG1 [33%] | DX4, PPO, PM6, PRP, XMP, 9DG (P00492 [34%]) |
hpt (CD3231) | W1H7G6 [55%] | P00492 [34%] | DX4, PPO, PM6, PRP, XMP, 9DG (P00492 [34%]) |
aldh (CD2733) | - | P51648 [43%] | RLT, 1O8, DTT (P00352 [30%]); |