Skip to main content

Table 4 List of 29 potential targets associated with 125 potential binders based on sequence identity

From: A curated C. difficile strain 630 metabolic network: prediction of essential targets and inhibitors

Target (pair)a

Sequence identityb

DrugBank potential inhibitorsc

E.coli

Human

accC

P24182 [53%]

Q96RQ3 [48%]

LZJ, LZK, LZL, OA1, OA2, OA3, OA4, OA5, L21, L22, L23 (P24182 [53%]); BTI (Q99UY8 [48%]); BTN (P11498 [45%]); D1L, H1L (O00763 [32%])

adk

P69441 [52%]

P54819-2 [45%]

IPE (P30085 [32%])

crt1

M9BEQ1 [37%]

P30084 [44%]

QUE (Q6NVY1 [30%])

fabF

P0A6Q6 [49%]

Q9NWU1 [45%]

CER, P9A, PMN (P0AAI5 [50%]); TL5, TL6, P4T (P0A953 [38%]); TLM (P63454 [37%])

fabH

P0ACC7 [42%]

-

CER, 669, OCS (P0A6R0 [45%]); B82 (820 T1 [43%]); DCC, UDT, VZZ, D1T, DFD, MDX (P0A574 [37%])

fabZ

P0ADG7 [36%]

P20839 [35%]

QUE, 2BC, 2BE, 2RB, 3BE, 4BB, 4BE, AGI, EMO, SAK (Q5G940 [41%]); BDE (O25928 [41%])

glmU

P62617 [55%]

-

P21 (P43889 [42%])

guaB

P14900 [32%]

P20839 [35%]

MOA, RBV, CPR, VX-148 (P20839 [35%])

ispA

B1J028 [42%]

Q5T2R2 [31%]

IPR (Q83M58 [41%])

ispH

M8X9N5 [30%]

-

DMA, IPE (P62624 [30%])

ispF

P0AD61 [51%]

P14618-2 [44%]

FPP (Q8EBR3 [62%]); GPP (P62617 [55%]); IPP (A0R559 [34%])

murD

P0A858 [44%]

P60174-1 [44%]

LK1, LK2, LK3, LK4, LKM (P14900 [32%]);

ntpA

-

P38606 [51%]

ADH, 911, Tiludronate, BafilomycinA1, Bafilomycin B1 (P38606, [51%]); QUE, APP, AUR, PIT, TLX (P06576 [30%])

ntpB

-

P21281 [53%]

Gallium nitrate, AES (P21281 [53%]); QUE, APP, AUR, PIT, TLX (P06576 [30%])

pykF

A0A029KL96 [52%]

P14618-2 [44%]

D8G, DYY, DZG, PGA (P14618 [44%])

deoD (deoB, deoC)

L3ICZ2 [46%]

P00491 [48%]

IMH, 2DI, AZG, 9PP, IMG, GU7, BC3, 9DI (P00491 [48%])

fabG (CD2577)

P33898 [61%]

P04406 [44%]

EMO (P16544 [37%]); TAQ, CB3, DVP, FE1 (P0CG22 [34%]); MAX (Q6PKH6 [33%]); TDB (Q16698 [31%])

CD2577 (fabG)

N3Z8L0 [36%]

Q92506 [33%]

TCL, IDN, AYM, BGC, 654, ZAM, 826, NDT, (P0AEK4 [39%]); NAP, TDB (Q16698 [30%])

gapA (gapB)

P0A9B2 [52%]

O14556 [47%]

BRZ, NMD, TND (O14556 [44%]); AES (P04406 [49%])

gapB (gapA)

P25526 [35%]

P00352 [35%]

APR, SND, AES (P04406 [49%]); BRZ, NMD, TND (O14556 [47%])

uppS (CD2762)

P0A825 [56%]

P34897-3 [45%]

B08, B28, B29, B76, FPP, FPS, IPE (P60472 [44%]); GPP (P60379 [43%])

glyA (CD2834)

P0A825 [48%]

P34897-3 [41%]

PLP, THL (P34897 [45%]); Mimosine (P34896 [44%])

CD2834 (glyA)

-

B7ZLW7 [31%]

PLP, THL (P34897 [41%]); Mimosine (Pr4896 [40%])

CD0727 (folD | fhs | fchA)d

P24182 [53%]

Q96RQ3 [48%]

CNC, THL, I2A (Q99707 [31%])

scoB (folD | fhs | fchA)d

E9YQ86 [56%]

B7Z609 [51%]

SIN, EMT (P55809 [52%])

scoA (folD | fhs | fchA)d

G1YD51 [53%]

Q6IAV5 [42%]

SIN, EMT (P55809 [42%])

CD3231 (hpt)

W1H7G6 [47%]

Q9NRG1 [33%]

DX4, PPO, PM6, PRP, XMP, 9DG (P00492 [34%])

hpt (CD3231)

W1H7G6 [55%]

P00492 [34%]

DX4, PPO, PM6, PRP, XMP, 9DG (P00492 [34%])

aldh (CD2733)

-

P51648 [43%]

RLT, 1O8, DTT (P00352 [30%]);

  1. aGenes that are essential as part of a double mutant pair have the name of the partner gene identified in parenthesis.
  2. bUniprot ID of the closest sequence homolog.
  3. c3-letter PDB code of ligand that is a known inhibitor or binder of a sequence homolog with the Uniprot ID and the level of sequence identity given in parenthesis. Approved drugs are in italics.
  4. dThe target gene is part of more than one essential pairs, one with each of the proteins in parenthesis.