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Figure 2 | BMC Systems Biology

Figure 2

From: Analysis of the quantitative balance between insulin-like growth factor (IGF)-1 ligand, receptor, and binding protein levels to predict cell sensitivity and therapeutic efficacy

Figure 2

IGF1 availability was regulated by cell-mediated ligand depletion and IGFBP sequestration. A, IGF1 was depleted by OVCAR5 in the absence of IGFBPs. B, The majority of IGF1 added to conditioned media was sequestered by cell-secreted IGFBPs. *indicates significant difference (p < 0.05) from cell-free control for A or from serum-free media control for B, n = 3 per treatment.

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BMC Systems Biology

ISSN: 1752-0509

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