Table 3 Relevant ISHC parameters and corresponding in silico intrinsic clearance values among validating runs
From: Toward modular biological models: defining analog modules based on referent physiological mechanisms
|  | Griffin and Houston[[33]] | Lavé et al.[[52]] | ||||
|---|---|---|---|---|---|---|
(CL= 8.9 ± 4.2 μL/min/106cells) | (CL= 51.0 μL/min/106cells) | |||||
Experiment number | 1 | 2 | 3 | 4 | 5 | 6 |
pExitMedia | 0.02 | 0.02 | 0.03 | 0.2 | 0.18 | 0.2 |
pExitCell | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 0.85 |
pBind | 0.25 | 0.25 | 0.25 | 0.25 | 0.5 | 0.5 |
pMetabolize | 0.5 | 0.25 | 0.25 | 0.5 | 0.5 | 0.5 |
dosage | 10000 | 10000 | 10000 | 10000 | 10000 | 10000 |
CL (μL/min/10 6 cells) | 9.59 ± 0.22 | 8.71 ± 0.34 | 12.82 ± 0.43 | 48.53 ± 0.79 | 48.36 ± 0.64 | 53.30 ± 0.94 |