Table 4 Reactions associated with Terpenoids backbone biosynthesis pathway that were added to the model Tfu_v3 for the simulation of Secondary metabolites pathway central hub

R00238

acetyl-CoA C-acetyltransferase

2.3.1.9

[c]: C00024 -- > C00332

R01978

hydroxymethylglutaryl-CoA synthase

2.3.3.10

[c]: C00332 + C00024 -- > C00356

R02082

3-hydroxy-3-methylglutaryl-CoA reductase

1.1.1.34

[c]: C00356 -- > C00418

R02245

mevalonate kinase

2.7.1.36

[c]: C00418 -- > C01107

R03245

phosphomevalonate kinase

2.7.4.2

[c]: C01107 -- > C01143

R01121

diphosphomevalonate decarboxylase

4.1.1.33

[c]: C01143 -- > C00129

R01123

isopentenyl-diphosphate delta-isomerase

5.3.3.2

[c]: C00129 -- > C00235

R05636

DOXP synthase (Dxs)

2.2.1.7

[c]: C00118 + C00022 -- > C11437

R05688

DOXP reductase (Dxr)

1.1.1.267

[c]: C11437 -- > C11434

R05633

MEP synthase (IspD)

2.7.7.60

[c]: C11434 -- > C11435

R05634

CDP-ME kinase (IspE)

2.7.1.148

[c]: C11435 -- > C11436

R05637

CDP-MEP synthase (IspF)

4.6.1.12

[c]: C11436 -- > C11453

R08689

HMB-PP synthase (IspG)

1.17.4.3

[c]: C11453 -- > C11811

R05884

HMB-PP reductase (IspH)

1.17.7.1

[c]: C11811 -- > C00129

R08209

HMB-PP reductase (IspH)

1.17.1.2

[c]: C11811 -- > C00129

R01123

IPP delta-isomerase

5.3.3.2

[c]: C00129 -- > C00235