Figure 10From: Identification of network-based biomarkers of cardioembolic stroke using a systems biology approach with time series dataCell cycle Role of SCF complex in cell cycle regulation which is the third scored pathway map in MetaCore enrichment analysis results. The Skp, Cullin, F-box containing complex (SCF complex) play critical roles in the ubiquitination of proteins involved in cell cycle regulation. Ubiquitin was down-regulated in stoke samples at 3, 5, 24 hours and overall stroke samples as compared with control. NEDD8 was up-regulated in stoke samples at 5 hours and overall stroke samples.Back to article page