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Figure 6 | BMC Systems Biology

Figure 6

From: Disentangling the multigenic and pleiotropic nature of molecular function

Figure 6

Networks of functional links (edges) between pathways (nodes). Node colour indicates functional organisation of genes within the pathway: the network shows the position of pathways with overlapping functionality (dark grey), discrete functionality (red), pleiotropic genes (green) and a single function (light grey). Nodes showing discrete functionality (see Figure 5B) and pleiotropic genes (see Figure 5C) tend to form clusters and are particularly frequent within energy metabolism. Pathways with both discrete and pleiotropic function (blue) are seen linking discrete and pleiotropic pathways. The size of the nodes indicates the number of GO annotations attributed to each pathway. Square nodes indicate the five pathways with the highest betweenness centrality. Pathways with as few as two annotations have discretely distributed functionality or pleiotropic genes.

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