Figure 2
From: Disentangling the multigenic and pleiotropic nature of molecular function
Functional Profile creation. (A) The figure shows one pathway, with genes represented as circles and gene annotations shown in boxes to the right of each gene. The aim of the algorithm is to select the minimum number of GO annotations necessary to represent all the genes in the pathway, preferentially selecting annotations with low enrichment scores. In this example GO 5 is the annotation with the lowest enrichment score and is therefore selected first. GO 5 is associated with genes 1 and 2, therefore GO 5 is sufficient to represent these genes. GO 4 is selected next and represents genes 2, 3, and 4; therefore GO 4 and GO 5 represent all the genes in the pathway.