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Table 1 Optimal parameters and averaged time-dependent AUCs of each network using 5-fold cross validation on training data

From: Investigating the utility of clinical outcome-guided mutual information network in network-based Cox regression

Profile

Network

σ

λ

α

Mean (time AUC)

CNA

Mutual Information

0.30

10−3

0.1

0.5875

 

Correlation

-

10−3

0.9

0.5817

 

Functional Linkage

-

10−3

0.3

0.5786

 

L2 − Cox

-

10−3

1.0

0.5810

mRNA

Mutual Information

0.10

10−4

0.1

0.6317

 

Correlation

-

10−4

0.9

0.6280

 

Functional Linkage

-

10−4

0.3

0.6242

 

L2 − Cox

-

10−4

1.0

0.6288

METH

Mutual Information

0.30

10−4

0.5

0.5912

 

Correlation

-

10−4

0.7

0.5894

 

Functional Linkage

-

10−4

0.3

0.5860

 

L2 − Cox

-

10−4

1.0

0.5899