Table 2 Table 1
| Â | ARL | FBL | FFL | bi-fan | SIM |
|---|---|---|---|---|---|
A The total number of the five motif types identified for cancer networks and STNs | |||||
Cancer networks | |||||
Pathways in cancer | 0 | 0 | 1 | 73 | 27 |
AML | 0 | 0 | 0 | 9 | 12 |
Glioma | 0 | 0 | 0 | 9 | 6 |
Melanoma | 0 | 0 | 0 | 1 | 4 |
NSCLC | 0 | 1 | 2 | 4 | 7 |
PC | 0 | 0 | 1 | 0 | 5 |
RCC | 0 | 0 | 1 | 0 | 3 |
Signal transduction networks (STNs) | |||||
Erbb | 0 | 0 | 5 | 69 | 17 |
FoxO | 0 | 0 | 3 | 0 | 3 |
Hippo | 0 | 0 | 2 | 0 | 8 |
Jak-Stat | 0 | 0 | 0 | 4 | 3 |
Mapk | 0 | 0 | 1 | 6 | 32 |
PI3k-Akt | 0 | 0 | 1 | 1 | 10 |
Rap1 | 0 | 0 | 0 | 1 | 13 |
Ras | 0 | 0 | 2 | 15 | 18 |
TGF_Beta | 0 | 0 | 0 | 1 | 7 |
TNF | 0 | 0 | 0 | 1 | 11 |
TCS | 0 | 0 | 0 | 3 | 35 |
VEGF | 0 | 0 | 2 | 0 | 5 |
Wnt | 0 | 0 | 11 | 0 | 7 |
* TCS denotes the Two-component system | |||||
B The total number of SIM motifs identified in cancer networks and STNs | |||||
Cancer networks | SIM | ||||
Basal cell carcinoma | 1 | ||||
Bladder cancer | 1 | ||||
Chronic myeloid leukemia | 4 | ||||
Colorectal cancer | 4 | ||||
Endometrial cancer | 4 | ||||
Pancreatic cancer | 8 | ||||
Small cell lung cancer | 2 | ||||
Signal transduction networks (STNs) | 9 | ||||
Calcium signaling | 3 | ||||
Hedgehog | 6 | ||||
HIF-1 | 6 | ||||
mTOR | 10 | ||||
NFkB | 2 | ||||
Notch | 2 | ||||
Phosphatidylinositol signaling system | Â | ||||