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Table 2 Top 10 hub genomic features impacting the largest number of genes.

From: Relative impact of multi-layered genomic data on gene expression phenotypes in serous ovarian tumors

Genomic feature

Type

N

Most significant GO term

p-value (FDR)

Most significant SP-PIR keyword

p-value (FDR)

hsa.miR.768.5p

miRNA

303

GO:0005739

mitochondrion

8.67E-09

(1.18E-05)

acetylation

1.10E-22

(1.40E-19)

hsa.miR.29a

miRNA

154

GO:0007049

cell cycle

7.99E-20

(1.21E-16)

cell cycle

7.30E-17

(1.44E-13)

SPRY4

methylation

119

GO:0003723

RNA binding

3.19E-4

(0.4197)

acetylation

1.09E-6

(0.0013)

16p13.3

CNA

117

GO:0031974

membrane-enclosed lumen

4.10E-5

(0.0506)

iron-sulfur

9.98E-5

(0.1257)

12q23.1

CNA

113

GO:0070013

intracellular organelle lumen

4.29E-5

(0.0534)

acetylation

2.62E-6

(0.0032)

1q42.3

CNA

113

GO:0012505

endomembrane system

7.3E-4

(0.8908)

phosphoprotein

4.71E-6

(0.0059)

6p21.1

CNA

109

GO:0042974

retinoic acid receptor binding

4.86E-8

(6.38E-5)

nucleus

1.84E-5

(0.0228)

17q25.3

CNA

108

non-membrane-bounded

organelle

0.0092

(11.23)

acetylation

6.39E-9

(8.03E-6)

1p36.11

CNA

103

GO:0016071

mRNA metabolic process

0.0046

(6.86)

phosphoprotein

1.31E-4

(0.1632)

19p13.12

CNA

102

GO:0043232

intracellular non-membrane-bounded

organelle

1.24E-5

(0.0150)

nucleus

1.24E-5

(0.0149)

  1. The most significantly enriched GO terms and SP-PIR keywords for the set of associated genes are listed together.