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Table 1 Assessment of the stringent and the conventional DDI-based approaches through gold standard H. sapiens PPIs.

From: Stringent DDI-based Prediction of H. sapiens-M. tuberculosis H37Rv Protein-Protein Interactions

Conventional DDI-based Approach

Overlap with Gold Standard

Top 3085 PPIs

81

Top 885 PPIs

11

Stringent DDI-based Approach

Overlap with Gold Standard

All 839 PPIs

82

  1. This table summarizes the assessment of the stringent and the conventional DDI-based approaches through gold standard human PPIs. In order for the conventional DDI-based approach to attain an amount of overlap with gold standard human PPIs similar to the stringent DDI-based approach, a much larger number of (false positive) predicted PPIs must be accepted. Conversely, if the conventional DDI-based approach is restricted to a similar number of predictions as the stringent DDI-based approach, a much lower overlap with gold standard human PPIs must be accepted.