From: Inferring protein domains associated with drug side effects based on drug-target interaction network
Rank | Weight | Side effect | Protein domain ID | Protein domain definition |
---|---|---|---|---|
1 | Â | anaphylaxis | Â | Â |
 | 330.0000 |  | PF13558 | SbcCD_C (Putative exonuclease SbcCD, C subunit) |
 | 320.0000 |  | PF00060 | Lig_chan (Ligand-gated ion channel) |
 | 115.8250 |  | PF08491 | SE (Squalene epoxidase) |
 | 113.4802 |  | PF00989 | PAS (PAS fold) |
 | 74.9419 |  | PF05790 | C2-set (Immunoglobulin C2-set domain) |
2 | Â | tardive dyskinesia | Â | Â |
 | 330.0000 |  | PF10320 | 7TM_GPCR_Srsx (Serpentine type 7TM GPCR chemoreceptor Srsx) |
3 | Â | labyrinthitis | Â | Â |
 | 330.0000 |  | PF10316 | 7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc) |
 | 70.4820 |  | PF10140 | YukC (WXG100 protein secretion system (Wss), protein YukC) |
4 | Â | shortness of breath | Â | Â |
 | 330.0000 |  | PF02898 | NO_synthase (Nitric oxide synthase, oxygenase domain) |
 | 325.3147 |  | PF10324 | 7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw) |
 | 324.4456 |  | PF02931 | Neur_chan_LBD (Neurotransmitter-gated ion-channel ligand binding domain) |
 | 100.7863 |  | PF10320 | 7TM_GPCR_Srsx (Serpentine type 7TM GPCR chemoreceptor Srsx) |
5 | Â | priapism | Â | Â |
 | 330.0000 |  | PF10324 | 7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw) |
 | 112.9922 |  | PF10316 | 7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc) |
 | 2.0630 |  | PF00206 | Lyase_1 (Lyase) |
6 | Â | nasal congestion | Â | Â |
 | 330.0000 |  | PF10324 | 7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw) |
 | 330.0000 |  | PF10316 | 7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc) |
7 | Â | weakness | Â | Â |
 | 330.0000 |  | PF10324 | 7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw) |
8 | Â | burning sensation | Â | Â |
 | 327.1335 |  | PF10316 | 7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc) |
 | 14.2660 |  | PF02867 | Ribonuc_red_lgC (Ribonucleotide reductase, barrel domain) |
 | 7.4168 |  | PF03522 | KCl_Cotrans_1 (K-Cl Co-transporter type 1 (KCC1)) |
 | 5.7520 |  | PF10324 | 7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw) |
 | 0.3741 |  | PF00209 | SNF (Sodium:neurotransmitter symporter family) |
9 | Â | glycosuria | Â | Â |
 | 326.7361 |  | PF00191 | Annexin (Annexin) |
 | 145.3436 |  | PF08377 | MAP2_projctn (MAP2/Tau projection domain) |
 | 49.9279 |  | PF03491 | 5HT_transporter (Serotonin (5-HT) neurotransmitter transporter, N-terminus) |
 | 48.0767 |  | PF02222 | ATP-grasp (ATP-grasp domain) |
 | 32.5342 |  | PF00698 | Acyl_transf_1 (Acyl transferase domain) |
10 | Â | hypoventilation | Â | Â |
 | 292.0382 |  | PF02898 | NO_synthase (Nitric oxide synthase, oxygenase domain) |
 | 281.0425 |  | PF02931 | Neur_chan_LBD (Neurotransmitter-gated ion-channel ligand binding domain) |