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Table 2 Examples of highly weighted protein domains for each side effect inferred by the L1LOG method

From: Inferring protein domains associated with drug side effects based on drug-target interaction network

Rank

Weight

Side effect

Protein domain ID

Protein domain definition

1

 

anaphylaxis

  
 

330.0000

 

PF13558

SbcCD_C (Putative exonuclease SbcCD, C subunit)

 

320.0000

 

PF00060

Lig_chan (Ligand-gated ion channel)

 

115.8250

 

PF08491

SE (Squalene epoxidase)

 

113.4802

 

PF00989

PAS (PAS fold)

 

74.9419

 

PF05790

C2-set (Immunoglobulin C2-set domain)

2

 

tardive dyskinesia

  
 

330.0000

 

PF10320

7TM_GPCR_Srsx (Serpentine type 7TM GPCR chemoreceptor Srsx)

3

 

labyrinthitis

  
 

330.0000

 

PF10316

7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc)

 

70.4820

 

PF10140

YukC (WXG100 protein secretion system (Wss), protein YukC)

4

 

shortness of breath

  
 

330.0000

 

PF02898

NO_synthase (Nitric oxide synthase, oxygenase domain)

 

325.3147

 

PF10324

7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw)

 

324.4456

 

PF02931

Neur_chan_LBD (Neurotransmitter-gated ion-channel ligand binding domain)

 

100.7863

 

PF10320

7TM_GPCR_Srsx (Serpentine type 7TM GPCR chemoreceptor Srsx)

5

 

priapism

  
 

330.0000

 

PF10324

7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw)

 

112.9922

 

PF10316

7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc)

 

2.0630

 

PF00206

Lyase_1 (Lyase)

6

 

nasal congestion

  
 

330.0000

 

PF10324

7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw)

 

330.0000

 

PF10316

7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc)

7

 

weakness

  
 

330.0000

 

PF10324

7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw)

8

 

burning sensation

  
 

327.1335

 

PF10316

7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc)

 

14.2660

 

PF02867

Ribonuc_red_lgC (Ribonucleotide reductase, barrel domain)

 

7.4168

 

PF03522

KCl_Cotrans_1 (K-Cl Co-transporter type 1 (KCC1))

 

5.7520

 

PF10324

7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw)

 

0.3741

 

PF00209

SNF (Sodium:neurotransmitter symporter family)

9

 

glycosuria

  
 

326.7361

 

PF00191

Annexin (Annexin)

 

145.3436

 

PF08377

MAP2_projctn (MAP2/Tau projection domain)

 

49.9279

 

PF03491

5HT_transporter (Serotonin (5-HT) neurotransmitter transporter, N-terminus)

 

48.0767

 

PF02222

ATP-grasp (ATP-grasp domain)

 

32.5342

 

PF00698

Acyl_transf_1 (Acyl transferase domain)

10

 

hypoventilation

  
 

292.0382

 

PF02898

NO_synthase (Nitric oxide synthase, oxygenase domain)

 

281.0425

 

PF02931

Neur_chan_LBD (Neurotransmitter-gated ion-channel ligand binding domain)