Table 2
From: A networks method for ranking microRNA dysregulation in cancer
Pathway Name | Description | Relevant miRNA Targeted Proteins |
|---|---|---|
Apoptosis | Process of programmed cell death | APAF1, BAK1, BCL2, BNIP3L, CASP6, CASP7, CDKN2A, FADD, FAS, IGF1R, JUN, MCL1, MYC, PIK3R1 |
E2F regulation of DNA replication | E2F family of transcription factors affects cell cycle progression, apoptosis and DNA synthesis. | CCNE1, CDC25A, DHFR, E2F1, E2F2, E2F3, PRIM1, RB1, TYMS |
TRKA signaling | Activation leads to cell survival and replication | ADCY6, AKT2, CDKN1A, CDKN1B, CRK, FOXO1, IRS1, KRAS, MAPK12, MAPK14, MAPK7, MTOR, NRAS, PIK3R1, PTEN, RHOA |
miR-17-92 cluster/ E2F | Regulation of E2F and Myc by members of miR-17-92 cluster | E2F1, E2F2, E2F3, MYC |
IL2 signaling events mediated by STAT5 | Cytokine signaling pathway involved in immune response to foreign infection | BCL2, CCNA2, CCND3, CDK6, FOXP3, JAK1, MYC, PIK3R1, SP1 |
ErbB Signaling | ErbB family of receptor tyrosine kinases regulates motility, survival, apotosis, proliferation | CCND1, CDKN1A, CDKN1B, CRK, EGFR, ERBB2, ERBB3, FOXO1, JUN, KRAS, MTOR, MYC |
G1/S Transition | Cell cycle checkpoint | CCND1, CDK4, CDKN1A, CDKN1B, CDKN2A, E2F1, E2F2 |
IL-4 Signaling | Regulates immune response signaling including B cell proliferation, T and B cell survival, production of immunoglobulins, and chemokine production. | BCL2, CCNA2, CCND3, CDK6, FOXP3, JAK1, MYC, PIK3R1, SP1 |
Cell Cycle | Cell division, replication, and maturation. | CCNA2, CCND3, CCNE1, CDC14B, CDC25A, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, E2F1, E2F2, E2F3, PLK1, RB1 |