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Table 5 Gene Ontology (GO) Biological Processes enriched in clusters of differential co-expression protein interaction modules

From: Dynamic protein interaction modules in human hepatocellular carcinoma progression

Cluster

GOID

Term

# expec-ted genes

# genes

Adjusted p-value *

I

GO:0071842

cellular component organization at cellular level

23.3

44

0.0002

I

GO:0007346

regulation of mitotic cell cycle

2.6

12

0.0004

I

GO:2000241

regulation of reproductive process

1.2

8

0.0006

I

GO:0009968

negative regulation of signal transduction

4.3

15

0.0006

I

GO:0043066

negative regulation of apoptotic process

4.9

16

0.0006

I

GO:0031577

spindle checkpoint

0.4

5

0.0007

I

GO:0032088

negative regulation of NF-kappaB transcription factor activity

0.4

5

0.0007

I

GO:0000086

G2/M transition of mitotic cell cycle

1.3

8

0.0007

I

GO:0048522

positive regulation of cellular process

23.2

41

0.0007

I

GO:0006366

transcription from RNA polymerase II promoter

10.2

24

0.0007

I

GO:0042221

response to chemical stimulus

20.2

37

0.0008

I

GO:0031623

receptor internalization

0.4

5

0.0008

I

GO:0048468

cell development

10.5

24

0.0008

I

GO:0050658

RNA transport

1.0

7

0.0008

I

GO:0016032

viral reproduction

3.7

13

0.0009

II

GO:0043065

positive regulation of apoptotic process

2.0

11

0.0003

II

GO:0006366

transcription from RNA polymerase II promoter

4.3

15

0.0005

III

GO:0016567

protein ubiquitination

4.5

17

0.0001

III

GO:0000075

cell cycle checkpoint

2.7

13

0.0001

III

GO:0042981

regulation of apoptotic process

12.9

30

0.0001

III

GO:0000165

MAPK cascade

4.4

16

0.0001

III

GO:0032268

regulation of cellular protein metabolic process

12.6

29

0.0001

III

GO:0010627

regulation of intracellular protein kinase cascade

5.7

18

0.0002

III

GO:0050863

regulation of T cell activation

2.4

11

0.0002

III

GO:0007346

regulation of mitotic cell cycle

3.3

13

0.0002

III

GO:0044419

interspecies interaction between organisms

4.4

15

0.0003

III

GO:0006511

ubiquitin-dependent protein catabolic process

4.0

14

0.0003

III

GO:0045892

negative regulation of transcription, DNA-dependent

7.7

20

0.0005

III

GO:0007265

Ras protein signal transduction

2.8

11

0.0006

III

GO:0007173

epidermal growth factor receptor signaling pathway

1.9

9

0.0007

III

GO:0051090

regulation of sequence-specific DNA binding transcription factor activity

3.3

12

0.0007

III

GO:0009967

positive regulation of signal transduction

6.7

18

0.0007

III

GO:0016310

phosphorylation

13.6

28

0.0008

III

GO:0045732

positive regulation of protein catabolic process

0.8

6

0.0008

III

GO:0030518

intracellular steroid hormone receptor signaling pathway

1.1

7

0.0008

III

GO:0042770

signal transduction in response to DNA damage

1.5

8

0.0009

III

GO:0080134

regulation of response to stress

6.9

18

0.0009

III

GO:0008285

negative regulation of cell proliferation

5.1

15

0.0009

IV*

GO:0044419 *

interspecies interaction between organisms

2.1

11

0.0020

IV*

GO:0000904 *

cell morphogenesis involved in differentiation

3.3

12

0.0099

IV*

GO:0007165 *

signal transduction

18.8

33

0.0099

V

GO:0065008

regulation of biological quality

4.1

13

0.0008

V

GO:0001775

cell activation

1.4

8

0.0009

V

GO:0018193

peptidyl-amino acid modification

1.0

7

0.0009

V

GO:0048011

nerve growth factor receptor signaling pathway

0.5

5

0.0009

V

GO:0043066

negative regulation of apoptotic process

1.1

7

0.0009

V

GO:0000165

MAPK cascade

0.8

6

0.0009

V

GO:0042060

wound healing

1.2

7

0.0009

V

GO:0045860

positive regulation of protein kinase activity

0.8

6

0.0009

V

GO:0071375

cellular response to peptide hormone stimulus

0.5

5

0.0009

  1. * Threshold value for adjusted p-value is 0.01 (Cluster IV) or 0.001 (clusters I, II, III, and V). No GO term was found to be enriched for cluster VI with either threshold value.