Skip to main content

Table 6 Topics found by GeneTopics for GWA studies measuring metabolite level changes

From: GeneTopics - interpretation of gene sets via literature-driven topic models

Topic

Topic words

pvalue

Topic 23

liver, human, glucuronidation, activities, metabolic, microsomal, enzyme, p450, ugts, ugt1a9, ugt1a1, udpglucuronosyltransferase, ugt1a6, substrate, ugt1a7, cyp3a5, ahr, drug, hepatitis, metabolites

2.29E-19

Topic 28

enzyme, activities, substrate, structure, acid, cytochrome, residues, purified, reaction, inhibited, oxidation, formed, inhibitor, dehydrogenase, electron, ph, crystal, coli, binding, production

1.73E-08

Topic 22

apo, lipoprotein, apolipoproteins, cholesterol, lipids, plasma, hdl, triglyceride, lipase, apoa, apoc, ldl, tg, level, metabolic, el, cetp, particles, density, hepatitis

3.55E-05

Topic 17

patients, or, treatment, study, clinic, groups, diseases, therapy, tested, years, method, assessed, evaluate, response, cases, who, p, rate, after, treated

7.63E-05

Topic 5

level, increased, p, rat, after, activities, effect, groups, concentration, control, decreased, or, mrna, days, compared, not, h, plasma, blood, higher

0.000175

Topic 4

transporter, uptake, renal, acid, organization, cation, kidney, cotransporter, membranes, amino, taurine, choline, intestinal, rat, apical, anions, octn2, tubule, microm, drug

0.000581

Topic 38

associated, polymorphism, allele, genotype, gene, variants, risk, study, patients, genetic, p, or, population, control, diseases, 95, snps, haplotype, frequency, significance

0.004274

Topic 16

mutations, patients, gene, deficiency, syndrome, caused, family, diseases, disorders, phenotype, identified, genetic, analysis, clinic, reporter, defective, severely, cases, exons, affected

0.011144