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Table 2 Topics found for GAD genetic diseases gene set

From: GeneTopics - interpretation of gene sets via literature-driven topic models

GAD gene set

LDA model #

Relevant number of topics

Best Topic

esophageal cancer

20

7

genotyp,polymorph,risk,associ,cancer,95,gstm1,gene,or,ci,control,studi,allel,gstt1,p,patient,genet,gstp1,frequenc,signific

kidney cancer

15

2

polymorph,xrcc1,risk,repair,cancer,genotyp,dna,95,associ,ci,gene,allel,variant,control,patient,suscept,breast,frequenc,case,ratio

Alzheimer's disease

15

10

polymorph,genotyp,associ,allel,risk,gene,patient,p,popul,genet,95,variant,diseas,haplotyp,diabet,subject,frequenc,ci,snps,control

blood pressure, arterial

20

11

polymorph,genotyp,gene,associ,allel,p,risk,variant,hypertens,patient,genet,subject,popul,95,haplotyp,frequenc,ci,variat,studi,pressur

carotid atherosclerosis

10

6

eno,endotheli,ace,oxid,rat,inhibitor,nitric,group,renal,p,inhibit,day,treatment,synthas,after,vascular,arteri,heart,angiotensin,enzym

hypertension

20

14

arteri,rat,angiotensin,pressur,vascular,hypertens,heart,cardiac,receptor,renal,blood,ang,increas,ace,endotheli,ventricular,express,after,at1,muscl

cirrhosis

10

5

iron,transferrin,receptor,tfr,hfe,ferritin,cell,stfr,method,uptak,serum,assay,status,sampl,antibodi,marrow,recycl,blood,concentr,defici

hepatitis c, chronic

10

7

polymorph,il12b,genotyp,associ,allel,risk,gene,frequenc,patient,haplotyp,genet,diseas,suscept,p,popul,asthma,ci,il12,variant,95

longevity

15

7

polymorph,genotyp,gstm1,gene,risk,associ,gstt1,cancer,allel,frequenc,genet,95,null,ci,patient,control,variant,popul,individu,p

diabetes, type 2

20

14

polymorph,associ,genotyp,gene,allel,p,risk,diabet,variant,patient,subject,genet,popul,snps,type,frequenc,haplotyp,95,2,studi

  1. This table shows the best topic found by GeneTopics for gene sets derived from GAD (Genetic Association Database). Many of the best topics found are related to the common origins of the GAD gene sets.