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Figure 4 | BMC Systems Biology

Figure 4

From: Identification of mutated core cancer modules by integrating somatic mutation, copy number variation, and gene expression data

Figure 4

The first module identified by iMCMC in the ovarian carcinoma data and locations of the detected genes in known pathways. (A) All pairs of genes in this module are highly mutually exclusive with values more than 0.90. (B) The detected genes MYC and CCNE1 are in the cell cycle pathway. The dense dashed line represents pair of genes with exclusivity more than 0.90 and correlation larger than 0.20. RAD52 plays a central role in genetic recombination and DNA repair, and is not only highly exclusive but also correlated with MYC and CCNE1.

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BMC Systems Biology

ISSN: 1752-0509

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