From: A 3D multiscale model of cancer stem cell in tumor development
Parameter Symbol | Parameter Annotation | Parameter Value | Reference |
---|---|---|---|
D n | Diffusion rate of Nutrient | 1.0 | P. Macklin et al. (2009) |
D c | Diffusion rate of TAF | 100 | Estimated |
D m | Diffusion rate of MDE | 1.0 | P. Macklin et al. (2009) |
| Uptake rate of Nutrient | [0.2, 0.5, 0.33, 0.67, 1, 1] | X. Zheng et al. (2005); Estimated |
| Binding rate of nutrient | 2.5·e-3 | Estimated |
| Nutrient transfer rate from neo-vasculature | 0.05 | X. Zheng et al. (2005); Estimated |
| Nutrient transfer rate from existing vessel | 0.01 | Estimated |
| TAF secretion rate by dying cells | 0.05 | Estimated |
| TAF secretion rate by viable cells | 0.004 | Estimated |
| TAF degradation rate | 0.01 | P. Macklin et al. (2009) |
| TAF uptake rate by endothelial cells | 0.025 | P. Macklin et al. (2009) |
| MDE secretion rate by viable cells | {50, 100, 150} | P. Macklin et al. (2009); Estimated |
| MDE secretion rate by endothelial cells | 1.0 | P. Macklin et al. (2009) |
| MDE degradation rate | 10 | P. Macklin et al. (2009) |
| ECM secretion rate by viable cells | 0.1 | P. Macklin et al. (2009) |
| ECM secretion rate by endothelial cells | 0.01 | Estimated |
| ECM degradation rate | 0.01 | P. Macklin et al. (2009) |
λ a | Volume loss rate due to apoptosis | 0~0.00013 | Estimated |
λ N | Volume loss rate due to necrosis | 0.25 | X. Zheng et al. (2005) |
θ a | Nutrient dose for cell survival | {0.1, 0.17, 0.25} | X. Zheng et al. (2005); Estimated |
θ d | Maximum drug concentration for cell survival | {0.25, 0.27, 0.375} | Estimated |
[K CC , K CCP , K CP , K CT ] | CSC proliferation probabilities | {0.6, 0.25, 0.1, 0.05} | Estimated |
[K PP , K PT ] | PC proliferation probabilities | {0.25, 0.75} | Estimated |
[K TT , d T ] | TC proliferation probability | [1- λ a , λ a ] | Estimated |
A p | Relative proliferation ages | [1, 0.4, 1, 0.2] | Estimated |
G m | Maximum generations a cell can divide | [250, 50, 25] | Estimated |
C s | Constant for cell size scaling | 10·e-5 | Estimated |