Optimization and model reduction in the high dimensional parameter space of a budding yeast cell cycle model

BMC Systems Biology

Table 7 Strongly connected phenotype-model parameter pairs

Phenotype	Perturbed model parameter	Probability of phenotype loss
cdc15 Δ net1-ts cdh1 Δ	Total amount of Cdc14	1.00
cdc15 Δ net1-ts cdh1 Δ	Total amount of Net1	0.99
CLB2-db Δ multicopy SIC1	Basal SBF dephosphorylation	0.93
CLB2-db Δ multicopy SIC1	SBF-dependent Cln2 synthesis	0.90
cln1,2 Δ cdh1 Δ GAL-CLN2	Total amount of Esp1	0.89
CLB2-db Δ multicopy SIC1	CKI phosphorylation rate	0.88
cdc15 Δ net1-ts cdh1 Δ	Efficiency of Cdc14-Net1 complex (RENT) formation	0.88
cln1,2 Δ cdh1 Δ GAL-CLN2	PPX inactivation by Esp1	0.87
GALL-CDC20 sic1 Δ cdh1 Δ	Degradation rate of Cdc20	0.87
cdc15-ts multicopy CDC14	Total amount of Net1	0.87

Upon a perturbation, with at least 0.87 probability, these parameters caused the loss of the corresponding phenotype (all phenotypes are experimentally viable).

ISSN: 1752-0509