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Table 3 Biologic functional analysis of highly central genes

From: Transcriptome meta-analysis reveals a central role for sex steroids in the degeneration of hippocampal neurons in Alzheimer’s disease

Bioinformatics Platform

Disease

p-value

IPA

Alzheimer's Disease

4.40E-08

Parkinson's Disease

2.88E-04

Huntington's Disease

1.28E-03

MetaCore

Neurodegenerative Diseases

4.20E-25

Dementia

5.98E-24

Alzheimer's Disease

3.30E-23

Parkinson's Disease

2.15E-13

DAVID

Alzheimer's Disease

1.40E-03

 

Parkinson's Disease

1.10E-02

  1. IPA, MetaCore, and DAVID analysis of neurological disease enrichment. The diseases identified were based on the 73 genes that are highly central in the PPI network.