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Table 4 NADH balance

From: A metabolite-centric view on flux distributions in genome-scale metabolic models

Producing fluxes

Reaction/Enzyme

Pathway/Product

Ratio

glyceraldehyde-3-phosphate dehydrogenase

glycolysis

52.74%

pyruvate dehydrogenase

glycolysis/TCA cycle

32.14%

malate dehydrogenase

TCA cycle

5.35%

phosphoglycerate dehydrogenase

Ser

4.31%

2-oxoglutarate dehydrogenase

TCA cycle

2.78%

3-isopropylmalate dehydrogenase

Leu

1.11%

IMP dehydrogenase

purines

0.60%

histidinol dehydrogenase

His

0.47%

prephenate dehydrogenase

Tyr

0.34%

glycine cleavage system

folate metabolism

0.14%

Consuming fluxes

Reaction/Enzyme

Pathway/Product

Ratio

NADH dehydrogenase

oxidative phosphorylation

94.48%

enoyl-[acyl-carrier-protein] reductase (11 reactions)

fatty acids

5.10%

methylenetetrahydrofolate reductase

Met

0.40%

  1. Total flux: 33.7 mmol gDW−1 h−1. Ratios below 0.05% not shown.
  2. Abbreviations: His, Leu, … – biosynthesis of L-amino acids.