Figure 1

Focality and recurrence scores measure the presence of a given gene in alterations in tumor samples. The focality score (left) assigns equal weight to all genes participating in a genomic alteration inversely proportional to the size of that alteration, while recurrence score (right) assigns equal weight to all genes altered in a sample inversely proportional to the total number of gene altered in the sample. In the figures, the alterations occurring in a particular sample are represented by segmented horizontal lines and each segment is a particular gene. For example, the top sample has three alterations with one, two, and one genes, respectively.