Table 4 Disease network top 20 significant connections PPP model

1

Muscular dystrophy-dystroglycanopathy (limb-girdle)

Muscular dystrophy-dystroglycanopathy (congenital)

2

2

13.31

2

Zellweger syndrome

Adrenoleukodystrophy

14

14

12.06

3

Leber congenital amaurosis

Retinitis pigmentosa

6

6

10.12

4

Neuropathy

Charcot-Marie-Tooth disease

12

12

8.99

5

Blood group

Malaria

13

13

8.76

6

Ullrich congenital muscular dystrophy

Bethlem myopathy

14

14

8.57

7

Iminoglycinuria

Hyperglycinuria

14

14

8.57

8

Usher syndrome

Deafness

8

8

8.48

9

Hemolytic uremic syndrome

Macular degeneration

10

10

8.24

10

Bronchiectasis with or without elevated sweat chloride

Pseudohypoal-dosteronism

11

11

7.75

11

Refsum disease

Zellweger syndrome

14

14

7.14

12

Meckel syndrome

Joubert syndrome

6

6

7.08

13

Omenn syndrome

Severe combined immunodeficiency

14

14

6.99

14

Left ventricular noncompaction

Cardiomyopathy

12

12

6.97

15

Mitochondrial complex I deficiency

Leigh syndrome

2

2

6.85

16

Alport syndrome

Hematuria

14

14

6.70

17

Colorblindness

Blue cone monochromacy

14

14

6.70

18

Atrial fibrillation

Long QT syndrome

2

2

6.64

19

Cone-rod dystrophy

Retinitis pigmentosa

6

6

6.56

20

Microphthalmia with coloboma

Microphthalmia

6

6

6.46