Cluster and propensity based approximation of a network

BMC Systems Biology

Table 2 Disease network top 20 significant connections CPBA

	Disease 1	Disease 2	C1	C2	−Log₁₀(P)
1	Zellweger syndrome	Adrenoleukodystrophy	14	14	8.57
2	Muscular dystrophy-dystroglycanopathy (limb-girdle)	Muscular dystrophy-dystroglycanopathy (congenital)	2	2	7.05
3	Ullrich congenital muscular dystrophy	Bethlem myopathy	14	14	6.48
4	Iminoglycinuria	Hyperglycinuria	14	14	6.48
5	Alport syndrome	Hematuria	14	14	5.31
6	Colorblindness	Blue cone monochromacy	14	14	5.31
7	Refsum disease	Zellweger syndrome	14	14	5.05
8	Usher syndrome	Retinitis pigmentosa	8	6	5.04
9	Seckel syndrome	Microcephaly	14	14	4.96
10	Leukoencephalopathy with vanishing white matter	Ovarioleukodystrophy	14	14	4.96
11	Omenn syndrome	Severe combined immunodeficiency	14	14	4.90
12	Tuberous sclerosis	Lymphangioleio-myomatosis	14	14	4.60
13	Cone-rod dystrophy	Macular degeneration	6	10	4.60
14	Bronchiectasis with or without elevated sweat chloride	Pseudohypoaldoste-ronism	11	11	4.47
15	Leri-Weill dyschondrosteosis	Langer mesomelic dysplasia	14	14	4.10
16	Multiple pterygium syndrome	Myasthenic syndrome	14	14	4.00
17	Craniofacial-deafness-hand syndrome	Waardenburg syndrome	3	11	3.77
18	Nicotine addiction	Epilepsy	3	8	3.76
19	Hirschsprung disease	Pheochromocytoma	11	2	3.70
20	Langer mesomelic dysplasia	Short stature	14	14	3.62

ISSN: 1752-0509