Table 1 Basic parameter sets (PS) used in the model
From: A kinetic model for RNA-interference of focal adhesions
Focal adhesion parameters | ||||
|---|---|---|---|---|
Parameter | PS1 | PS2 | PS3 | Source |
α A | 10000 | 1000 | 10 | [70], this paper |
δ A | 1 | 100 | 1 | [70], this paper |
α I | 100 | 1000 | 100 | [70], this paper |
δ I | 100 | 100 | 100 | [70], this paper |
α AC | 0.1 | 0.01 | 100 | [70], this paper |
δ AC | 10 | 10 | 10 | [70], this paper |
α CI | 10 | 10000 | 0.01 | [70], this paper |
δ CI | 100 | 10 | 100 | [70], this paper |
τ ACI | 10 | 10 | 10 | this paper |
ε | 0.001 | 0.001 | 0.001 | this paper |
χ | 0.001 | 0.001 | 0.001 | this paper |
σ | 1.0 | 1.0 | 1.0 | this paper |
RNAi parameters | ||||
Parameter | PS1 | PS2 | PS3 | Source |
k MA | 17.3 | 17.3 | 17.3 | this paper |
k MC | 17.3 | 17.3 | 17.3 | this paper |
k MI | 17.3 | 17.3 | 17.3 | this paper |
d MA | 17.3 | 17.3 | 17.3 | this paper |
d MC | 17.3 | 17.3 | 17.3 | this paper |
d MI | 17.3 | 17.3 | 17.3 | this paper |
k T,A | 2.07681 | 0.735221 | 1.03706 | this paper |
k T,C | 2.07437 | 0.0206286 | 1.03476 | this paper |
k T,I | 2.59193 | 0.652918 | 2.08517 | this paper |
d A | 10 | 10 | 10 | this paper |
d C | 10 | 10 | 10 | this paper |
d I | 10 | 10 | 10 | this paper |
d | 60.0 | 60.0 | 60.0 | this paper |
[siRNA]MAX | 1.0 | 1.0 | 1.0 | this paper |
r siRNA | 10−4 | 10−4 | 10−4 | this paper |
Γ | 0.1 | 0.1 | 0.1 | this paper |
h | 4.5 | 4.5 | 4.5 | [72] |
Rac & Rho parameters | ||||
Parameter | PS1 | PS2 | PS3 | Source |
κ RAC | 1.0 | 1.0 | 1.0 | this paper |
κ RHO | 1.0 | 1.0 | 1.0 | this paper |
β RAC | 1.0 | 1.0 | 1.0 | [87, 88] |
β RHO | 1.0 | 1.0 | 1.0 | [87, 88] |
K RAC | 1.0 | 1.0 | 1.0 | [87, 88] |
K RHO | 1.0 | 1.0 | 1.0 | [87, 88] |
γ RAC | 4 | 4 | 4 | this paper |
γ RHO | 4 | 4 | 4 | this paper |
v | 1.0 | 1.0 | 1.0 | this paper |
ρ RAC | 1.0 | 1.0 | 1.0 | this paper |
ρ RHO | 1.0 | 1.0 | 1.0 | this paper |