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Figure 3 | BMC Systems Biology

Figure 3

From: A multi-level multi-scale approach to study essential genes in Mycobacterium tuberculosis

Figure 3

Network topology of protein-protein interactome and an example gene KO analysis. a) Shows the overall topology of the protein-protein interaction network used in this study. The network consists of 1240 nodes and 7844 edges. Essential genes were identified by systematic KO of each node in the network and by calculating the number of paths perturbed; b) illustrates the path between Rv3441c (mrsA) and Rv1240 (mdh) in the WT network. Nodes involved in the path are coloured green. c) Represents an alternate (but unlikely to be feasible) path between Rv3441c (mrsA) and Rv1240 (mdh), when Rv3436c (glmS) is knocked out. The purple triangle shows the node which is knocked out. Green nodes represent the original path in the WT network and red nodes are the reprogrammed alternate path that the system takes upon KO.

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