Figure 6

Comparison of the composite model simulation results with the experimental data by Neumann et al. The simulated concentrations of the original and reduced models (solid lines), as well as the simulated values of the composite model (dashed lines) were obtained by Neumann et al.[18] for three different concentrations of anti-CD95: 1500 ng/ml (black), 500 ng/ml (blue), and 250 ng/ml (red). We did not recalculate the relative experimental data (dots) as in the case of the Bentele’s model due to a slight difference between the results of the composite and precursor models. An exception was made for values of procaspase-3 and caspase-3, which were normalized for the composite model by the term 0.1 for convenience of the visual plots comparison.