Figure 1
From: Model composition through model reduction: a combined model of CD95 and NF-κB signaling pathways
Schematic representation of the model reduction technique. A model consisting of four species (A, B, C, and D) and two reactions (r1 and r2) was reduced taking into account the relations between time-dependent concentrations C A (t) and C B (t), as well as reaction rates vr1(t) and vr2(t). In the case when C A (t) ≫ C B (t), the concentration of A can be considered constant for some period of time. The same simplification could be applied to B. If vr1(t) ≈ vr2(t), then C could be removed, resulting in direct formation of D triggered by the binding of A and B only.