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Table 3 GO biological process terms of 17 differentially expressed genes mapped to the hallmarks of cancer

From: Identification of ovarian cancer associated genes using an integrated approach in a Boolean framework

Gene/cancer hallmark

HM1

HM2

HM3

HM4

HM5

HM6

HM7

HM8

HM9

HM10

KLK6

 

GC

  

G, GC

    

G, GC

IRAK1

 

GC

 

GC

   

GC

 

GC

CDC7

G

G,GC

 

G, GC

  

GC

G

  

CHEK1

G

G

 

G

  

G, GC

G

  

BUB1

   

G

  

GC

   

CHEK2

   

G, GC

  

G, GC

   

STC2

GC

GC

L

L

      

DAB2

GC

  

G, GC

GC

  

GC

  

VIM

  

GC

  

GC

    

FOXL2

   

GC

GC

GC

GC

   

LCN2

  

L

  

L

    

PGR

GC

         

AR

GC

GC

 

G, GC

      

IGF1R

 

G, GC

G, GC

G, GC

 

G, GC

 

G

GC

 

LYN

GC

 

GC

GC

 

GC

GC

 

GC

 

IGFBP7

G, GC

G

 

G, GC

   

G

  

CLU

  

GC

GC

    

GC

 
  1. HM1: sustain growth signal, HM2: escape growth suppressor i.e. insensitivity to growth inhibitor, HM3: active invasion and metastasis, HM4: limitless replicative potential/enable replicative immortality, HM5: induce angiogenesis, HM6: resist cell death, HM7: cause genomic instability, HM8: deregulate cellular energetic, HM9: avoid immune destruction, HM10: tumor promoting inflammation, G: GATHER [71], GC: GeneCards [72], L: literature (G details in Additional file 8 and GC and L details in Additional file 9).
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