Figure 5

Simulations of chronic irradiation. Constant kill rates are applied to S, CG and PGB (with k _CG  = k _PGB  = 0.66 k _S ). Cell numbers in S, CG, PGB and GRA are recorded after 100 days. a) In the ODE model reductions in S and CG are similar. PGB and GRA almost maintain cell numbers at low doses. At higher doses cell numbers in PGB and GRA decrease rapidly. b,c) In the hybrid model damage in S is smaller than in all other compartments. b) If both GEs Α and Ω are damaged, the system is sensitive to kill rates that are an order of magnitude smaller than for the ODE model. c) If damage is restricted to GE Ω, the SCC is more robust at kill rates comparable to those of the ODE model. All other compartments are more sensitive in comparison to stem cells.