BMC Systems Biology

Table 2 Number of essential proteins with low-connectivity or high-connectivity identified by ION and eight other existing centrality methods

From: Iteration method for predicting essential proteins based on orthology and protein-protein interaction networks

	K	DC	IC	EC	SC	BC	CC	NC	PeC	ION
deg<=10	1%	0	0	0	0	0	0	0	0	17
	5%	0	0	0	0	0	0	3	40	66
	10%	0	0	0	0	1	0	27	84	108
	15%	0	0	8	8	18	7	66	117	146
	20%	0	0	28	28	41	20	101	153	188
	25%	11	20	73	73	76	55	156	192	253
deg > 10	1%	22	24	24	24	24	24	32	39	24
	5%	101	102	96	96	95	104	156	133	122
	10%	207	210	195	195	181	193	255	209	223
	15%	320	316	271	271	253	277	307	255	299
	20%	413	406	349	349	320	344	363	285	359
	25%	491	484	394	394	357	393	388	302	381

The top part and the bottom part of this table are the number of essential proteins with low-connectivity (degree < =10) and high-connectivity (degree > 10) identified by different methods, when selecting top K percent of proteins (top 1%, 5%, 10%, 15%, 20%, 25%).

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ISSN: 1752-0509

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