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Figure 4 | BMC Systems Biology

Figure 4

From: Iteration method for predicting essential proteins based on orthology and protein-protein interaction networks

Figure 4

PR curves of ION and eight other existing centrality methods. The proteins ranked in top K (cut-off value) by each method (ION, DC, BC, CC, SC, EC, IC, NC and PeC) are selected as candidate essential proteins (positive data set) and the remaining proteins in PPI network are regarded as candidate nonessential proteins (negative data set). With different values of K selected, the values of precision and recall are computed for each method. The values of precision and recall are plotted in PR curves with different cut-off values. (a) shows the PR curves of ION, PeC, NC and DC. (b) shows the PR curves of ION and two global centrality methods: BC and CC, and other tree centrality methods: IC, EC and SC.

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