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Figure 4 | BMC Systems Biology

Figure 4

From: Different designs of kinase-phosphatase interactions and phosphatase sequestration shapes the robustness and signal flow in the MAPK cascade

Figure 4

An implicit negative feedback loop from Phos2 to MKKK in the system M4K1. (A) Kinetics of MKKK-P in M4K1 (M4 with Michaelis Menten kinetics) for a low (5 nM) and a high (1000 nM) Phos2 concentration is shown for unsequestrated (USEQ) condition. and phosphatase sequestrated (PSEQ) conditions. MKKK-P phosphorylation kinetics for low and high Phos2 concentrations is given by black and red dotted lines respectively. (B) Kinetics of MKKK-P in M4K1 (M4 with Michaelis Menten kinetics) for a low (5 nM) and a high (1000 nM) Phos2 concentration is shown for phosphatase sequestrated (USEQ) condition. (C) Steady state phosphorylation amplitude of MKKK-P at various concentrations of Phos2 is shown. Steady state MKKK-P amplitude in PSEQ and USEQ conditions are given with blue and green dotted lines.

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