Term | Definition | Description |
---|---|---|
True postive (TP) | In silico: viable phenotype | Results where the metabolic model predicts a viable phenotype and the actual phenotype is also viable |
 | In vivo: viable phenotype |  |
True negative (TN) | In silico: lethal phenotype In vivo: lethal phenotype | Results where the metabolic model predicts a lethal phenotype and the actual phenotype is also lethal |
False positive (FP) | In silico: viable phenotypeIn vivo: lethal phenotype | Results where the metabolic model predicts a viable phenotype but the actual phenotype is lethal |
False negative (FN) | In silico: lethal phenotype In vivo: viable phenotype | Results where the metabolic model predicts a lethal phenotype but the actual phenotype is viable |
Overall accuracy | (TP + TN)/(TP + TN + FP + FN) | Percentage of correct predictions by the metabolic model |
Negative prediction rate | (TN)/(TN + FN) | Percentage of negative predictions that are correctly predicted as lethal |
Positive prediction rate | (TP)/(TP + FP) | Percentage of positive predictions that are correctly predicted as viable |
Sensitivity | (TP)/(TP + FN) | Percentage of viable predictions correctly predicted as positive |
Specificity | (TN)/(TN + FP) | Percentage of lethal predictions correctly predicted as negative |