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Table 4 Parameter estimations of the L. lactis model

From: Incremental parameter estimation of kinetic metabolic network models

 

Simultaneous method

Incremental method

 

min Φ C a

min Φ S

min Φ C

min Φ S

CPU time (sec)

>5 days

3476.89 ± 349.63

976.72 ± 31.01

20.82 ± 2.71

eSSM GO iterations

1662 ± 282

4 ± 1

33 ± 7

Φ C

Stiff ODE

2.20 ± 8.81 × 10-3

6.18 ± 7.28 × 10-2

Φ S

2.67 ± 1.93 × 10-4

1.51 × 103 ± 52.50

5.79 ± 9.62 × 10-4

  1. a. None of five runs finished with a relative improvement of the objective function below 1% within the 5-day time limit, after iterating for 60, 147, 93, 79 and 31 times. The corresponding Φ C at termination were 9.31, 7.57, 8.77, 9.39 and 12.9, respectively.