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Table 1 Kinetic parameters of enzyme catalytic cycles

From: Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approach

Parameter

Value

Units

V max PLA 2

450

μM/min

K m PLA 2 _ APC

20

μM

K Ca PLA 2

0.1

μM

K AA

10.7

μM

K 2 Ca

7.11

mM

K 2 Ca

14.4

μM

K ox

100

μM

K r

5.8 10-7

-

K AA i

552

μM

K HT

0.54

μM

K d3

1.3 10-4

-

k lo

4.6 103

1/min

k 3

0.34 103

(min· μM)-1

k ox

2.7 10-4

(min· μM)-1

k ox2

67.2

(min· μM)-1

k r

2.54 10-4

1/min

k r2

4.4 10-5

1/min

k LTAsyn

5.4 10-4

1/min

k ing

16450

1/min

K dz

36.6

μM

K PF

0.126

uM

K GSSG gpx

0.072

μM

k cat gpx

0.489

1/min

K NADP hedh

2.9

μM

K NADPH hedh

2.69

μM

K oxoETE hedh

1.67

μM

K HT hedh

0.332

μM

k 1 hedh

88.34

1/min

k 2 hedh

1724

1/min

k - 1 hedh

31.5

1/min

k - 2 hedh

8.08

1/min

k HTd

0.001

1/min

k LTAd

0.07

1/min

k oxoETEd

0.005

1/min