Skip to main content

Table 2 Parameters of transcription and translation

From: A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen

Process

Rate constant

Value in the model, s-1

Existing experimental estimates, s-1

Reference

mRNA synthesis induced by ER2-hormone complexes

k sr

0.195

0.125-0.2

[74]

mRNA synthesis induced by ER2-inhibitor complexes

k sr,i

0.02

-

 

mRNA synthesis induced by ER2-hormone-inhibitor complexes

k sr,hi

0.05

-

 

mRNA synthesis induced by ER2

k sr,b

0.001

-

 

mRNA degradation

k dr *

(0.0025)*

0.001-0.003

[74]

   

1.5×10-4-0.005

[75]

Protein synthesis

k sp *

(0.001)*

3×10-4 - 0.03

[76]

Protein degradation

k dp *

(2×10-5)*

1.4×10-5 -3×10-5

[76]

Constant ratio k dp k dr k sp

κ

5×10-5

  
  1. Parameters marked (*) could not be evaluated independently. Use of the dose dependence data only allowed estimation of the ratio κ, as defined in equation (22). The given values are realistic estimates of k dr , k sp and k dp chosen to satisfy the equation for κ (see Additional File 3 for further details).