Figure 1

Fragmentation analysis of the global network. The original global unfragmented network (a), the impact on the network connectivity due to the removal of the sixteen genes belonging to the SCC (b), and an example of the removal of sixteen genes randomly selected (c). In (b) most of the genes become disconnected and the size of the giant component or the biggest connected graph is only 38 genes. In (c) when removing 16 randomly selected genes, the mean of the giant component was 81.02 nodes (standard deviation of 8.29) for 1000 removals . This figure illustrates the relevant role of the SCC as a connectivity element of the network.