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Table 3 Candidate targets to sensitize epithelial tumours to therapy

From: Dynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention

Mutated Protein in Tumor

     Candidate targets to sensitize tumours to therapies inducing

 

DNA SSBs

DNA DSBs

p53

ATM-P & ATR

ATM-P

ATM-P & Chk1-P & Chk2-P

ATR & Chk2-P & FKBP51*

ATM-P & Chk2-P & c-Rel

ATR & Chk2-P & IKK_complex-P*

ATM-P & Chk2-P & IKK_complex-P

ATR & Chk2-P & IKKϵ-P*

ATR & Chk2-P & FKBP51*

ATR & Chk2-P & p50-p65-P*

ATR & Chk2-P & IKK_complex-P*

Chk2-P & IKK_complex-P & LUBAC*

ATR & Chk2-P & IKKϵ-P*

Chk2-P & IKK_complex-P & MK2-P*

ATR & Chk2-P & p50-p65-P*

Chk2-P & IKK_complex-P & TAK1-P*

ATR & MRN

Chk2-P & IKK_complex-P & TRAF6*

Chk1-P & Chk2-P & MRN

Chk2-P & IKK_complex-P & XIAP*

Chk2-P & c-Rel & MRN

MRN

Chk2-P & IKK_complex-P & LUBAC*

PP5

Chk2-P & IKK_complex-P & MK2-P*

Chk2-P & IKK_complex-P & MRN

Chk2-P & IKK_complex-P & TAK1-P*

Chk2-P & IKK_complex-P & TRAF6*

Chk2-P & IKK_complex-P & XIAP*

PP5

HIPK2

ATM-P & ATR

ATM-P

ATM-P & Chk1-P & Chk2-P

MRN

ATM-P & Chk2-P & c-Rel

PP5

ATM-P & Chk2-P & IKK_complex-P

ATR & MRN

Chk1-P & Chk2-P & MRN

Chk2-P & c-Rel & MRN

Chk2-P & IKK_complex-P & MRN

PP5

ATM

ATR*

No targets found.

Chk1-P & Chk2-P*

Chk2-P & c-Rel*

Chk2-P & IKK_complex-P*

PP5

Chk2

ATM-P & ATR

ATM-P

ATM-P & Chk1-P*

ATR & BARD1-BRCA1-P & FKBP51*

ATM-P & c-Rel*

ATR & BARD1-BRCA1-P & IKK_complex-P*

ATM-P & IKK_complex-P*

ATR & BARD1-BRCA1-P & IKKϵ-P*

ATR & BARD1-BRCA1-P & FKBP51*

ATR & BARD1-BRCA1-P & p50-p65-P *

ATR & BARD1-BRCA1-P & IKK_complex-P*

ATR & FKBP51 & p53-P*

ATR & BARD1-BRCA1-P & IKKϵ-P*

ATR & IKK_complex-P & p53-P*

ATR & BARD1-BRCA1-P & p50-p65-P *

ATR & IKKϵ-P & p53-P*

ATR & FKBP51 & p53-P*

ATR & p53-P & p50-p65-P*

ATR & IKK_complex-P & p53-P*

IKK_complex-P & LUBAC & p53-P*

ATR & IKKϵ-P & p53-P*

IKK_complex-P & MK2-P & p53-P*

ATR & MRN

IKK_complex-P & p53-P & TAK1-P*

ATR & p50-p65-P & p53-P*

IKK_complex-P & p53-P & TRAF6*

Chk1-P & MRN*

IKK_complex-P & p53-P & XIAP*

c-Rel & MRN*

MRN

IKK_complex-P & LUBAC & p53-P*

PP5

IKK_complex-P & MK2-P & p53-P*

 

IKK_complex-P & MRN*

IKK_complex-P & p53-P & TAK1-P*

IKK_complex-P & p53-P & TRAF6*

IKK_complex-P & p53-P & XIAP*

 

PP5

 
  1. * Sets of targets whose inhibition might specifically sensitize tumor cells with the indicated mutation, but allow normal cells to survive by entering cell cycle arrest.
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BMC Systems Biology

ISSN: 1752-0509

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