Table 2 Validation of the model on reported effects without functional p53
Inactivated Protein | DNA damage | Reported effects without functional p53 | References | Model prediction |
|---|---|---|---|---|
ATM | DSBs | · cell death enhanced | Jiang et al. 2009 | · cell cycle arrest blocked |
· anti-apoptotic NF-κB (p50-p65-P) blocked | ||||
· apoptosis diminished | ||||
Chk1 | SSBs | · cell cycle arrest diminished | Tse et al. 2007 | · Cdc25A degradation diminished (degradation of Cdc25A leads to cell cycle arrest) |
Ma et al. 2011 | ||||
· cell death enhanced | Garret and Collins 2011 | |||
· these effects of Chk1 inhibition are | ||||
more pronounced in p53-deficient cells than in cells with a functional p53 | ||||
Chk2 | DSBs | · cell death enhanced or cell death not enhanced? | Jiang et al. 2009 | · cell cycle arrest diminished |
· apoptosis diminished | ||||
Anderson et al. 2011 |