From: Computational modeling of apoptotic signaling pathways induced by cisplatin
Initial conditions | Â | ||
---|---|---|---|
OCT2 | 1 | Apoptosis | 0 |
ER | 1 | Aqcis | 0 |
Calpain | 1 | Calpain* | 0 |
Caspase-12 | 1 | Caspase-12* | 0 |
Caspase-9 | 1 | Caspase-9* | 0 |
Caspase-3 | 1 | Caspase-3* | 0 |
IAP | 1 | Caspase-9*·IAP | 0 |
DNA | 1 | DNA damage | 0 |
ATR | 1 | ATR* | 0 |
p53 | 1 | p53* | 0 |
AIFmit | 1 | AIF | 0 |
Bax | 1 | Bax·Bak | 0 |
Bcl-2 | 1 | p53*·Bcl-2 | 0 |
Mit | 1 | Cyt.c·Caspase-9 | 0 |
mitPTP | 1 | mitPTP* | 0 |
Cyt.cmit | 1 | Cyt.c | 0 |
Caspase-8 | 1 | Caspase-8* | 0 |
FasL | 1 | FasL* | 0 |
Caspase-2 | 1 | Caspase-2* | 0 |
Ca2+ | 0 | Caspase-8*·Caspase-3 | 0 |
Ca2+·Calpain | 0 | FasL*·Caspase-8 | 0 |
Calpain*·Caspase-12 | 0 | ATR*·p53 | 0 |
mitRos | 0 | Caspase-3*·IAP | 0 |
Caspase-12*·Caspase-9 | 0 | Caspase-9*·Caspase-3 | 0 |
p53*·Caspase-2 | 0 | p53*·Bax | 0 |
Bcl-2·Bax | 0 |  |  |