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Table 4 Ordinary differential equation

From: Computational modeling of apoptotic signaling pathways induced by cisplatin

Ordinary differential equations

d A q c i s / d t = k 1 + C i s O C T 2 d C a 2 + / d t = k 2 + A q c i s E R − k 3 + C a 2 + C a l p a i n + k 3 − C a 2 + ⋅ C a l p a i n d C a l p a i n / d t = − k 3 + C a 2 + C a l p a i n + k 3 − C a 2 + ⋅ C a l p a i n d C a 2 + ⋅ C a l p a i n / d t = k 3 + C a 2 + C a l p a i n + k 3 − C a 2 + ⋅ C a l p a i n − k 4 + C a 2 + ⋅ C a l p a i n d C a l p a i n * / d t = k 4 + C a 2 + ⋅ C a l p a i n − k 5 + C a l p a i n * C a s p 12 + k 5 − C a l p a i n * ⋅ C a s p 12 d C a s p 12 / d t = − k 5 + C a l p a i n * C a s p 12 + k 5 − C a l p a i n * ⋅ C a s p 12 d C a l p a i n * ⋅ C a s p 12 / d t = k 5 + C a l p a i n * C a s p 12 − k 5 − C a l p a i n * ⋅ C a s p 12 − k 6 + C a l p a i n * ⋅ C a s p 12 d C a s p 12 * / d t = k 6 + C a l p a i n * ⋅ C a s p 12 − k 7 + C a s p 12 * C a s p 9 + k 7 − C a s p 12 * ⋅ C a s p 9 d C a s p 9 / d t = − k 7 + C a s p 12 * C a s p 9 + k 7 − C a s p 12 * ⋅ C a s p 9 − k 27 + C y t c C a s p 9 + k 27 − C y t c ⋅ C a s p 9 d C a s p 12 * ⋅ C a s p 9 / d t = k 7 + C a s p 12 * C a s p 9 − k 7 − C a s p 12 * ⋅ C a s p 9 − k 8 + C a s p 12 * ⋅ C a s p 9 d C a s p 9 * / d t = k 8 + C a s p 12 * ⋅ C a s p 9 + k 9 − C a s p 9 * ⋅ C a s p 3 − k 9 + C a s p 9 * C a s p 3 − k 12 + C a s p 9 * I A P + k 12 − C a s p 9 * ⋅ I A P + k 28 + C y t c ⋅ C a s p 9

d A T R * / d t = k 15 + D N A d a m a g e A T R − k 16 + A T R * P 53 + k 16 − A T R * ⋅ P 53 d P 53 / d t = k 16 + A T R * P 53 + k 16 − A T R * ⋅ P 53 d A T R * ⋅ P 53 / d t = k 16 + A T R * P 53 − k 16 − A T R * ⋅ P 53 − k 17 + A T R * ⋅ P 53 d P 53 * / d t = k 17 + A T R * ⋅ P 53 + k 18 − P 53 * ⋅ C a s p 2 − k 18 + P 53 * C a s p 2 − k 22 + P 53 * B a x + k 22 − P 53 * ⋅ B a x − k 25 − P 53 * B c l 2 + k 25 − P 53 * ⋅ B c l 2 d C a s p 2 / d t = − k 18 + P 53 C a s p 2 + k 18 − P 53 * ⋅ C a s p 2 d P 5 3 * ⋅ C a s p 2 / d t = k 18 + P 5 3 * C a s p 2 − k 18 - P 53 * ⋅ C a s p 2 − k 18 - P 53 * ⋅ C a s p 2 d C a s p 2 / d t = k 19 + P 53 C a s p 2 − k 20 + C a s p 2 * A I F m i t d A I F m i t / d t = − k 20 + C a s p 2 * A I F m i t d A I F / d t = k 20 + C a s p 2 * A I F m i t d B a x / d t = - k 22 + P 53 * B a x + k 22 - P 53 * ⋅ B a x

d C a s p 3 * / d t = k 10 + C a s p 9 * ⋅ C a s p 3 + k 36 + C a s p 8 * ⋅ C a s p 3 − k 13 + C a s p 3 * I A P + k 13 − C a s p 3 * ⋅ I A P d I A P / d t = − k 12 + C a s p 9 * I A P + k 12 − C a s p 9 * ⋅ I A P − k 13 + C a s p 3 * I A P + k 13 − C a s p 3 * ⋅ I A P d C a s p 9 * ⋅ I A P / d t = k 12 + C a s p 9 * I A P − k 12 − C a s p 9 * ⋅ I A P d C a s p 3 * ⋅ I A P / d t = k 13 + C a s p 3 * I A P − k 13 − C a s p 3 * ⋅ I A P d D N A d a m a g e / d t = k 14 + A g c i s D N A

d P 53 * ⋅ B a x / d t = k 22 + P 53 * B a x − k 22 − P 53 * ⋅ B a x − k 23 − P 53 * ⋅ B a x d B a x ⋅ B a k / d t = k 23 + P 53 * ⋅ B a x d B c l 2 / d t = − k 25 + P 53 * B c l 2 + k 25 − P 53 * ⋅ B c l 2 − k 24 + B c l 2 B a x + k 24 − B c l 2 ⋅ B a x d P 53 * ⋅ B c l 2 / d t = k 25 + P 53 * B c l 2 − k 25 − P 53 * ⋅ B c l 2 d B c l 2 ⋅ B a x / d t = k 24 + B c l 2 B a x − k 24 − B c l 2 ⋅ B a x

 

d m i t R o s / d t = k 29 + A q c i s M i t d m i t P T P * / d t = k 30 + m i t R o s m i t P T P d C y t c mit / d t = − k 26 + B a x ⋅ B a k C y t c mit − k 31 + m i t P T P * C y t c mit d C y c t / d t = k 26 + B a x ⋅ B a k C y t c mit − k 27 + C y t c C a s p 9 + k 27 − C y t c ⋅ C a s p 9 + k 31 + m i t P T P * C y t c m i t d C y t c ⋅ C a s p 9 / d t = k 27 + C y t c C a s p 9 − k 27 − C y t c ⋅ C a s p 9 − k 28 + C y t c ⋅ C a s p 9 d F a s L * / d t = k 32 + A q c i s F a s L − k 33 + F a s L * C a s p 8 + k 33 − F a s L * ⋅ C a s p 8 d C a s p 8 / d t = − k 33 + F a s L * C a s p 8 + k 33 − F a s L * ⋅ C a s p 8 − k 34 + F a s L * ⋅ C a s p 8

 

d F a s L * ⋅ C a s p 8 / d t = k 33 + F a s L * C a s p 8 − k 33 - F a s L * ⋅ C a s p 8 − k 34 + F a s L * ⋅ C a s p 8 d C a s p 8 * / d t = k 34 + F a s L * ⋅ C a s p 8 − k 35 + C a s p 8 * C a s p 3 + k 35 - C a s p 8 * ⋅ C a s p 3 d C a s p 8 * ⋅ C a s p 3 d t = k 35 + C a s p 8 * C a s p 3 − k 35 - C a s p 8 * ⋅ C a s p 3 − k 36 + C a s p 8 * ⋅ C a s p 3 d A p o p / d t = k 11 + C a s p 9 * C a s p 3 * + k 21 + C a s p 2 * A I F + k 37 + C a s p 8 * C a s p 3 *