Figure 2From: Computational modeling of apoptotic signaling pathways induced by cisplatinSimulated results of the variables related to the death receptor pathway. (A) Cisplatin becomes aquated and toxic after its entry into cells, thus activating FasL. Aqcis, aquated cisplatin; FasL*, activated FasL. (B) Activated FasL binds caspase-8 and activates the initiator caspase-8. FasL*_Casp8, binding of FasL* and Casp-8; Casp8*, activated caspase-8; Casp8, procaspase-8. (C) The activated caspase-8 leads directly to the activation of downstream caspase-3 and causes apoptosis. Casp8*_casp3, binding of Casp8* and casp3; Casp3*, activated caspase-3. Interaction between activated caspase-8 and caspase-3 activation (D) or apoptosis (E). Casp8*  × 1.0, activated caspase-8 at baseline value; Casp8*  × 2.0, activated caspase-8 increase by twofold; Casp8*  ×  0.2, activated caspase-8 decrease by fivefold.Back to article page