Table 1 The numerical values of different parameters of bistable molecular loop.
From: Regulation of cytoplasmic polyadenylation can generate a bistable switch
Parameter | Description | Value/Range |
|---|---|---|
λ 1 | CaMKII degradation rate (In-active state) | [0.0001 (sec-1)] 0.001-0.00002(sec-1) |
λ 2 | CaMKII degradation rate (Active, phosphorylated) | [0.0001 (sec-1)] 0.001-0.00002(sec-1) |
k 1 | Association rate constant (Ca+2)4-CaM/CaMKII binding | 0.0011 (μM- 1sec-1) |
k2 | Dissociation rate constant CaCaM.CaMKII | 14 (sec-1) |
k 1 | Association rate constant CaMKIIAP/CaMKIIAP binding | 0.085; (μM-1 sec- ) |
k 2 | Dissociation rate constant CaMKIIAP.CaMKIIAP | 0.143 (sec-1) |
k 3 | Rate constant for Phosphorylation | 500 (sec-1) |
k 4 | Rate constant for CaMKIIAP dephosphorylation | 0.0012 (sec-1) |
k 5 | Association rate constant CaMKIIAP/CPEB1 binding | 0.0072;(μM-1sec-1) |
k55 | Dissociation rate constant CaMKIIAP .CPEB1 | 20(sec-1) |
k 6 | Rate constant for CPEB1 Phosphorylation | 0.962(sec-1) |
k10 | Association rate constant (Ca+2)4-CaM/CaMKII binding | 0.001 (μM 1sec-1) |
k1010 | Dissociation rate constant CaCaM.CaMKII | 0.8 (sec-1) |
k 7 | Rate constant for CPEB1 dephosphorylation | 0.012(sec-1) |
k 8 | Association rate constant PCPEB/E binding | 0.08(μM- 1sec-1) |
k88 | Dissociation rate constant PCPEB1.E | 10(sec-1) |
k 9 | Synthesis Rate of New CaMKII molecule through polyadenylation | 0.08(sec-1) |
Xbasal | Basal concentration of CaMKII | 0.0001 μM |